After returning to villainy, Loki caused the complete eradication of humankind in order to make his brother Thor suffer. Among the few survivors, Victor von Doom set out to acquire all of the powers possessed by the Stone Age Avengers, acquiring the Eye of Agamotto and Cloak of Levitation, a Spirit of Vengeance, the power of the Iron Fist, and the Star Brand; enslaving several monsters to serve as his heralds before setting off into space. Logan was resurrected by the Phoenix Force and set out into space as well. Thousands of years later, Thor had become the All-Father, with Asgard reigning over the other realms.
Traveling through time using the Pool of Forevers, Gorr arrived from Earth-616, bringing with him the All-Black symbiote and its horde of Black Berserkers. Using All-Black to construct an artificial planet to serve as his base, Gorr set about capturing and enslaving countless gods and goddesses - including several Asgardians, Thor's granddaughters among them - until only Thor was left. For nine hundred years, Thor battled the Black Berserkers and his growing despair, until the arrival of the Thor of Earth-616 restored his fighting spirit. Alongside his "past self" and an even younger incarnation of Earth-616 Thor abducted from the Viking Age, King Thor was able to put a stop to Gorr's plot to wipe out all gods across the temporal continuum and cast Gorr's dark world and All-Black into a black hole. Many of the gods captured by Gorr were given a new home in Asgard, while others chose to find new homes to settle in.
Millennia later, Galactus attacked Earth intending to devour it, and Thor and his granddaughters attempted to fend the cosmic entity off. Thor was forced to retrieve the All-Black symbiote from the black hole and was almost corrupted by it, but it transferred to Galactus during their battle and took him over. During the battle, Thor's divine blood was spilled onto the barren ground, revitalizing it; and he and his granddaughters were able to terraform Earth into New Midgard.
Loki traveled to Earth-616 in order to corrupt Thor and his "past self", but was repeatedly thwarted and imprisoned.
Earth-14412 was destroyed during the Incursions and Thor was recreated on Battleworld as the Lawspeaker of the Thor Corps. After the destruction of Battleworld, Reed Richards of Earth-616 set out to rebuild the Multiverse, and this reality was eventually brought back into existence.
While Thor and his granddaughters recreated humanity and sought to stave off the encroaching end of the universe, Galactus set out to destroy the cosmos until he was eaten by Ego the Living Planet. Taken over by the All-Black symbiote, Ego resumed destroying the cosmos until millennia later Loki took the primordial symbiote from him and destroyed him, setting out to kill Thor and become the end of everything.
By this point the gods who had been rescued from Gorr had all grown old and perished, leaving only Shadrak until he killed himself to save the Goddesses of Thunder from Loki's Necro-ravens. After a brutal battle that destroyed Asgard and extinguished the Sun, Thor was incapacitated by Loki. Before Loki could finish Thor off, he was impaled by the resurrected Gorr. Gorr and All-Father Thor battled across the cosmos, shattering planets and destroying stars, but even with Loki joining him Thor was defeated. The Goddesses of Thunder traveled to Indigarr and recruited the gods that Thor had sent there in the distant past, returning in time to rescue Thor and Loki. Decapitated, Gorr revealed that his body was just a construct of the All-Black symbiote, which proceeded to infect the very universe itself. Thor was able to destroy the All-Black symbiote, but the universe was left decimated and crumbling from entropy.
Thor departed to stave off the universe's collapse for as long as he could, while Loki sacrificed himself to rekindle the Sun; leaving the Goddesses of Thunder to watch over New Midgard. Logan was eventually resurrected by the Phoenix Force and joined the three goddesses in establishing a team of heroes to watch over the remnants of the cosmos.