ENTER: Werewolf By Night! Jack Russell and his lover Topaz are on their way to Transylvania in the hopes that there they can find a cure for Jack's werewolf curse. They are completely unaware that fate has intended that they cross paths with Dracula, lord of the vampires, who has returned to Transylvania that very night after an extended stay in London. Dracula has just returned to his castle where he looks upon old paintings of himself and his long dead wife Maria and reflects over the events that found him transformed into a vampire.
Meanwhile, in catacombs beneath Paris, Quincy Harker comes across the body of Blade the vampire hunter. Seeing that Blade has been bitten by Dracula, and assuming his ally to be dead, Quincy Harker gets a stake out and prepares to ram it through Blade's heart.
While back in Transylvania, Jack and Topaz stop at the Olde Boot Inn to get rooms for the night. There Topaz is approached by a drunk man named Scratcher, who makes a sloppy pass at the girl. Scratcher gets a punch in the mouth from Jack for his trouble, and although he doesn't cause anymore trouble, he vows to get revenge against Jack for that hit. In their rooms, Jack warns Topaz to lock up tight because there will be a full moon and Jack will transform into the Werewolf. Topaz tries to reassure Jack that she can control him like she did last time. Scratcher, meanwhile decides to go up into the room and try and stab Jack. Entering Topaz's room he is horrified to find that Jack has transformed into the Werewolf.
The Werewolf attacks Scratcher, knocking him down into the bar below, and beats the man out of the bar. With Scratcher dead, Topaz arrives and convinces the Werewolf that they must leave before someone finds out that they killed the sailor. They are then confronted by Dracula, who has witnessed the fight. When Dracula attempts to feed on Topaz, he finds that looking into her eyes causes him great pain. Trying to get her to stop looking at him prompts the Werewolf to attack Dracula. The vampire king easily tosses the beast aside, but finds that Topaz's gaze is too strong and flees the scene to find a fresh victim elsewhere.
The next day, Jack (back in human form) and Topaz travel to Russoff manor where they go looking for clues on how to cure himself of the werewolf curse. He reflects back on how his father was similarly cursed and killed by a mob firing silver bullets.