With a new motorcycle, Johnny signs up for the Desolation Run, a race across the most deserted area of the United States. Racing with him are recent divorcees Terry Fairbanks and Nora Joyce, the widowed and ruined Douglas Forester, and the ignored Lemuel Driftwood, all of whom are partaking in the race for various reasons.
As they race across the desert, the demon Inferno locates the Hulk and sends the beast on a rampage across the desert in hopes that the Hulk will destroy Blaze. As night falls, Blaze becomes the Ghost Rider and is attacked by the Hulk. During the fight, the other bikers work together to help defeat the Hulk.
Using his hellfire to overheat the green behemoth, all the bikers resolve their various differences and problems and finish the race, although none of them win the prize money, they all walk away gaining so much more.