After an experiment to map Peter's blood goes wrong, he temporarily loses his powers, but Peter later realises this could be a blessing and goes back to have his powers removed permanently, letting him lead a normal life. This leads to some very interesting issues, with a powerless Spidey being forced to go up against The Tarantula and The Scorpion (with a little help from the Black Cat), forcing him once again to get his powers back and don the mask of the Amazing Spiderman.