Yuriko Oyama is a cyborg with a self-repairing machine body and deadly Adamantium claws, being better known as the samurai warrior Lady Deathstrike. She is the daughter of Lord Dark Wind, an insane and abusive Japanese kingpin who invented a process to coat bones with the indestructible metal Adamantium. After putting an end to her father, Oyama became devoted to carry on his legacy by becoming obsessed with the mutant Wolverine, who had been unrightfully enhanced with Adamantium and disgraced Oyama's honor. To be as lethal as Wolverine, Oyama sacrificed her humanity and made a deal with the exquisite witch Spiral in order to be transformed into Lady Deathstrike.
Deathstrike's hate for Wolverine has led her to forge alliance with despicable elements, especially Donald Pierce and his Reavers. She is also closely associated with the mutant-hating militant, Reverend William Stryker. Her activities usually lead her to clash with the mutant group which Wolverine is associated with, the X-Men.
More recently, Lady Deathstrike became a target of a rebranded Weapon X Project, which was particularly interested in seizing control of augmented subjects to serve as living weapons. After being rescued by a band of other victims, she joined them in a team who claimed the name Weapon X for themselves. Eventually, the group disbanded after their leader Sabretooth was gone during one last adventure.