When Elias Wirtham's older brother Joshua died of an incurable disease, Elias devoted himself to medicine, intending to save lives in honor of his brother's memory. In medical school, he roomed with Dr. Kevin Trench, and as his career began he befriended biotechnician Gerald Stone and industrialist Tony Stark, among others. Learning of a miracle drug that could have saved Joshua's life, Elias directed his flourishing company to take over the drug manufacturer. After acquiring the business assets, Elias was horrified to learn that the drug had been developed years ago, but the company had withheld releasing it in order to earn more money.
Now disgusted by his brother's meaningless death, Elias subjected himself to experiments that replaced his heart with a beta particle reactor, and fused a Vibranium mesh into his skin. Assuming the costumed guise of Cardiac, he set out to avenge the deaths of innocents at the hands of individuals who were untouchable by the law. When he targeted Justin Hammer's company Sapirdyne Chemicals for manufacturing cocaine, he encountered Hammer's enforcers Rhino and Boomerang , as well as the heroic Spider-Man (Peter Parker). Cardiac admired Spider-Man as a hero, and made repeated fruitless attempts to make Spider-Man his ally.
